野生動物疫病與免疫研究中心

發布時間:2019-08-01

  2018年野生動物疫病與免疫研究中心組建,現有人員14人,其中研究員1名,副研究員1名,助理研究員7名,研究生11名。研究中心以國家和廣東省戰略需求為導向,旨在聚焦現代農業、保護生物學等領域國際前沿與研究熱點,圍繞野生動物健康與病原生物學、環境微生物資源開發和生態治理、耐藥性微生物與公共衛生健康核心科學問題,開展精準化、系統化的基礎應用研究,為廣東省野生動物保護、養殖業健康發展、生態環境治理和公共衛生安全服務。


科研方向

  1.微生物病原生態學

  2.野生動物疫病防控與免疫研究


科研團隊

  一級PI(中心主任)王承民

  王承民,河北承德人,廣東省科學院“引進領軍人才”,華南農業大學和河北農業大學碩士生導師?,F任廣東省科學院動物研究所野生動物疫病與免疫研究中心主任,微生物病原生態學研究組組長。1996-2003年在河北農業大學獲得學士和碩士學位,2007-2010年在中國科學院動物研究所獲得理學博士學位,2003-2007年在河南科技學院工作,2010-2018年在中國科學院動物研究所工作(2013年美國USDA學術交流),2018年至今在廣東省科學院動物研究所工作。近年來,主持或參加科技部十一五、十二五和十三五重點研發計劃,國家自然科學基金、中國科學院先導A等項目,在Cell Reports, Journal of Infectious Diseases, Reviews In Medical Virology,Frontiers in Cellular and Infection Microbiology, Frontiers in genetics, Journal of wildlife diseases,科學通報,生物化學與生物物理進展等發表文章72篇,其中SCI論文52篇,累計影響因子147.79,總被引用710率次。申請專利11項(授權4件,包括2件國際專利),編寫著作9部,其中英文著作1部,參與制定標準2項。

  二級PI:陳金平

  研究員,博士生導師?,F任廣東省科學院動物研究所副所長、野生動物疫病與免疫學研究中心副主任,野生動物疫病防控與分子生態學研究組組長。1999年-2002年獲得哈爾濱師范大學動物學碩士學位,2002年-2005年獲得中國科學院動物研究所生態學博士學位。1997年-2002年,在中國水產科學研究院黑龍江水產研究所工作;2005年-2006年,在中國科學院廣州生物醫藥與健康研究院工作,期間在法國國家自然博物館從事合作研究;2006年至今在廣東省科學院動物研究所工作;2014年-2015年,作為訪問學者在美國康奈爾大學獸醫學院從事分子疫苗相關研究。近年來主持國家、省、市等各類科研項目15項;獲得獲廣東省科學技術二等獎1項,廣東省自然科學二等獎1項;發表學術論文91篇,其中SCI收錄 69 篇。申請國家發明專利12件,其中授權8件,申請國際發明專利1件。    

  研究組:

  1.微生物病原生態學研究組 組長:王承民 副研究員

  微生物病原生態學研究組于2018年9月成立,圍繞微生物開展研究工作,主要設置微生物耐藥與公共衛生安全、環境微生物與生態治理、噬菌體資源與產業化等三個研究方向,基于微生物生物學特性、微生物基因組學、轉錄組學等手段,開展了耐藥性細菌在野生動物-家養動物-人-環境 生態圈的擴散、環境微生物生物表型和基因組特征等工作,現有人員9人,其中研究生3人,發表SCI文章54篇,申報專利5項,其中國際專利2項。

  2.野生動物疫病防控研究組 組長:陳金平 研究員

  野生動物疫病防控研究組共12人,其中博士7人,碩士2人,本科2人,其他1人,由高級職稱2人,博士后3人,助理研究員4人,研究實習員1人,碩士研究生1人,本科實習生1人組成,具有動物學、基因組學、遺傳育種學、分子生物學、生物技術等多學科背景,是一支年輕的團隊。

 

團隊照片


主要成果

  本團隊共主持國際、國家、省、市等各類項目20余項,目前在研國家項目2項,省、市項目6項。共發表SCI論文91篇(SCI收錄69篇);授權國家發明專利9件,其中8件,PCT專利2件,日本發明專利1件;獲廣東省科學技術二等獎1項,廣東省自然科學二等獎1項。

  科技獎項

  1、2018年,“我國鱘魚資源評價、性腺發育研究及應用”獲2017年度廣東省科技進步二等獎。

  2、2019年,“蝙蝠特殊生存策略的機理研究”獲2018年度廣東省自然科學獎二等獎

  

   

 

獲獎照片

  學術論文:

  1、Ping Liu#, Jingzhe Jiang#, Xiufeng Wan, Yan Hua, Linmiao Li, Jiabin Zhou, Xiaohu Wang, Fanghui Hou, Jing Chen, Jiejian Zou, Jinping Chen*, Are pangolins the intermediate host of the 2019 novel coronavirus (SARS-CoV-2)?, PLoS Pathog, 2020,16(5): e1008421.

  2、Hafiz Ishfaq Ahmad, Jiabin Zhou , Muhammad Jamil Ahmad , Gulnaz Afzal, Haiying Jiang, Xiujuan Zhang, Abdelmotaleb A. Elokil, Musarrat Abbas Khan, Linmiao Li, Huiming Li, Liu Ping , Jinping Chen*. Adaptive selection in the evolution of programmed cell death-1 and its ligands in vertebrates. Aging, 2020, 12(4):3516-3557.

  3、Hafiz Ishfaq Ahmad, Akhtar Rasool Asif, Muhammad Jamil Ahmad, Farwa Jabbir , Muhammad Adnan, Shakeel Ahmed, Gulnaz Afzal, Ali Haider Saleem , Linmiao Li, Haiying Jiang , Mario Juan Simirgiotis , Mubashar Rauf, Jinping Chen*. Adaptive evolution of peptidoglycan recognition protein family regulates the innate signaling against microbial pathogens in vertebrates. Microbial Pathogenesis, 2020:104361.

  4、Huiming Li , Ping Liu , Xiujuan Zhang , Linmiao Li, Haiying Jiang , HuaYan , Fanghui Hou, Jinping Chen*. Combined proteomics and transcriptomics reveal the genetic basis underlying the diferentiation of skin appendages and immunity in pangolin. Scientific Reports. (2020) 10:14566 | https://doi.org/10.1038/s41598-020-71513-w.

  5、Huiming Li, Bize Yang, Xiujuan Zhang, Haiying Jiang, Linmiao Li, Hafz Ishfaq Ahmad, Jinping Chen*. Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris). Scientific Reports | (2020) 10:13920. https://doi.org/10.1038/s41598-020-70844-y.

  6、Huiming Li, Bize Yang, XueJun Jin, Jinping Chen*, Parentage and Genetic iversity Studies in Pangolin (Manis javanica) Using Novel Microsatellite Markers, Pakistan Journal of Zoology, Pakistan J. Zool., 2020, in press

  7、Jie Zhang* , Jiwei Qi , Fanglei Shi , Huijuan Pan , Meng Liu , Ran Tian , Yuepan Geng, Huaying Li , Yujie Qu , Jinping Chen*, Inge Seim* , Ming Li *, Insights into the evolution of neoteny from the genome of the Asian icefish Protosalanx chinensis, iScience 2020, 23, 101267 doi: https://doi.org/10.1016/j.isci.2020.101267.

  8、Haiying Jiang, Wu Chen, Li Su, Mingwei Huang, Libo Lin, Qiao Su, Guanyu Li, Hafiz Ishfaq Ahmad, Linmiao Li, Xiujuan Zhang, Huiming Li, Jinping Chen*. Impact of host intraspecies genetic variation, diet, and age on bacterial and fungal intestinal microbiota in tigers. MicrobiologyOpen. 2020, 00:e1050.

  9、Guoshuai Tang , Xixi Liang , Mengyuan Yang, Tingting Wang, Jinping Chen, Weiguo Du , Huan Li*, Baojun Sun*. Captivity Influences Gut Microbiota in Crocodile Lizards (Shinisaurus crocodilurus). Front. Microbiol. 11:550. doi: 10.3389/fmicb.2020.00550.

  10、Hafiz I. Ahmad, Fabiana Neves, Muhammad J. Ahmad, Sunny Ahmar, Abdelmotaleb A. Elokil, Jinping Chen*. The domestication makeup: evolution, survival, and challenges. Front. Ecol. Evol. 8:103.doi: 10.3389/fevo.2020.00103.

  11、Xiujuan Zhang, Jiabin Zhou, Linmiao Li, Wenzhong Huang, Hafiz Ishfaq Ahmad, Huiming Li, Haiying Jiang, Jinping Chen*. Full-length transcriptome sequencing and comparative transcriptomic analysis to uncover genes involved in early gametogenesis in the gonads of Amur sturgeon (Acipenser schrenckii). Zhang et al. Frontiers in Zoology (2020) 17:11 https://doi.org/10.1186/s12983-020-00355-z.

  12、Ping Liu, Wu Chen, Jinping Chen*, Viral Metagenomics Revealed Sendai Virus and Coronavirus infection of Malayan Pangolins (Manis javanica), Viruses, 2019, 11, 979.

  13、Juan Li, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Jinping Chen*. The effect of       disease and season to hepatopancreas and intestinal mycobiota of Litopenaeus vannamei, Frontiers in Microbiology, 2019, 10:889. 

  14、Haiying Jiang, Xiujuan Zhang, Linmiao Li, Jinge Ma, Nan He, Haiyang Liu, Richou Han, Huiming Li, Zhengjun Wu, Jinping Chen*. Identification of Austwickia chelonae as cause of cutaneous granuloma in endangered crocodile lizards using metataxonomics, Peer J, 2019, 7: e6574.

  15、Lihong Yuan, Linmiao Li, Xiujuan Zhang, Haiying Jiang, Jinping Chen*.        Identification and differential expression of piRNAs in the gonads of Amur sturgeon (Acipenser schrenckii), Peer J, 2019, 7: e6709. 

  16、Xiujuan Zhang, Guanyu Li, Haiying Jiang, Linmiao Li, Jine Ma, Huiming Li, Jinping Chen*. Full-length transcriptome analysis of Litopenaeus vannamei reveals transcript variants involved in the innate immune system. Fish and shellfish immunology, 2019, 87: 346-359.

  17、Jinge Ma, Haiying Jiang, Linmiao Li, Xiujuan Zhang, Huiming Li, Guanyu Li; Daying Mo, Jinping Chen*. SMRT sequencing of the full-length transcriptome of the Sunda pangolin (Manis javanica), gene, 2019, 692:208-216. 

  18、Xiahu Wang, Wu Chen, Rong Xiang , Linmiao Li, Jing Chen, Zhong RQ, Hua Xiang,  JinPing Chen *.Complete Genome Sequence of Parainfluenza Virus 5 (PIV5) from a Sunda Pangolin (Manis javanica) in China. Journal of Wildlife Disease,2019,55(4). DOI: 10.7589/2018-09-211.

  19、Liang Zhang, Haiying Jiang, Linmiao Li*, Jinping Chen. Complete mitochondrial genome of Opisthotropis andersonii (Serpentes: Colubridae) determined using next-generation sequencing. Mitochondrial DNA Part B-Resources,2019,4:1, 1012-1013.

  20、Jinge Ma, Haiying Jiang,Linmiao Li, Xiujuan Zhang,Guanyu Li, Huiming Li, Xuejun Jin, JinPing Chen *. The fecal metagenomics of Malayan pangolin identifies an extensive adaptation to myrmecophagy.Frontiers in microbiology, 2018, 9:2793.

  21、Haiying Jiang, Mingwei Huang, Libo Lin, Nan He, Jinping Chen*. Complete genome sequence of Austwickia chelonae LK16-18, isolated from crocodile lizards. Microbiology Resource Announcements, 2018, 7: e01140-18.

  22、Haiying Jiang, Libo Lin, Mingwei Huang, Yingan Zang, Jinping Chen*. Genome Sequence of Morganella morganii DG56-16, Isolated from Shinisaurus crocodilurus.2019, 8(4), e01301-18.

  23、Xiujuan Zhang, Jinge Ma, Linmiao Li, Haiying Jiang, Jinping Chen*. Effects of Different Cytoprotectants Combination on Sperm Survival, Fertility and Embryo Development in Amur Sturgeon (Acipenser schrenckii). Animal and Veterinary Sciences,2018; 6(4): 51-57

  24、Jinge Ma, Linmiao Li, Haiying Jiang, Xiujuan Zhang, Juan Li, Guanyu Li, Jinping Chen*. Acidic mammalian chitinase gene is highly expressed in the special oxyntic glands of Manis javanica, FEBS Open Bio,2018, 8(8):1247-1255.

  25、Juan Li, Linmiao Li, Haiying Jiang, Lihong Yuan, Libiao  Zhang, Jing?e Ma,  Xiujuan Zhang, Minhua Cheng, Jinping Chen*, Fecal Bacteriome and Mycobiome in Bats with Diverse Diets in South China, Current Microbiology, 2018, 75:1352–1361.

  26、Xiujuan Zhang, Linmiao Li, Haiying Jiang, Jing E. Ma, Juan Li, Jinping Chen*,Identification and differential expression of microRNAs in testis and ovary of Amur sturgeon (Acipenser schrenckii), Gene, 2018,658, 36-46.

  27、Haiying Jiang, Jinge Ma ,Juan Li, Xiujuan Zhang,  Linmiao Li , Nan He, Haiyang Liu , Shuyi Luo, Zhenjun Wu, Richou Han, Jinping Chen*,Diets alter the gut microbiome of Crocodile Lizards,Frontiers in Microbiology,2017, 8: 2073.

  28、Linmiao Li, Li Wei, Jinge Ma, Jinping Chen *,Development and characterization of 21 SNP markers in Manis javanica based on high-throughput sequencing,Conservation Genetics Resources,2018,10(3), 351-353.

  29、Jinge Ma,  Linmiao Li, Haiying Jiang, Xiujuan Zhang, Jun Li, Guanyu Li ,  Lihong Yuan, Jun Wu, Jinping Chen*,Transcriptomic analysis identifies genes and pathways related to myrmecophagy in the Malayan pangolin (Manis javanica),Peer J,2017,5:e4140.

  30、Haiying Jiang, Juan Li, Linmiao Li, Xiujuan Zhang, Lihong Yuan, Jinping Chen*. Selective evolution of Toll-like receptors 3, 7, 8, and 9 in bats. Immunogenetics, 2017, 69:271-285. 

  31、Xiujuan Zhang, Lihong Yuan, Linmiao Li, Haiying Jiang, Jinping Chen*. Conservation, sex-biased expression and functional annotation of microRNAs in the gonad of Amur sturgeon (Acipenser schrenckii). Comparative Biochemistry and Physiology, Part D, 2016, 18: 54–61.

  32、Le Han, Weijun He, Huixin Yan, Xianglan Li, Chengmin Wang,Qiumei Shi, Tiezhong Zhou,Guoying Dong. The evolution and molecular characteristics of H9N2 avian influenza viruses in Jiangxi of China. Journal of Medical Virology, 2019, 91:711-716.(IF= 2.049,期刊排名:116 / 272, Medicine, 2區.第5作者)

  33、Guoyao Ma, Lin Chen, Jing Luo, Bo Wang, Chengmin Wang, Meng, Chengmei Huang, Juan Du, Jiajun Ma, Yungfu Chang and Hongxuan He. Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway. Virology Journal, 2018,15:172( IF= 2.464,期刊排名:91 / 272, Medicine, 2區.第5作者)

  34、Meng Li,Lin Zhao,Jiajun Ma,Na Zhao,Jing Luo,Chengmin Wang,Lin Chen, Guoyao Ma,Yutian Wang,Hongxuan He. Vibrio vulnificus in aquariums is a novel threat to marine mammals and public health. Transbound Emerg Dis. 2018, 65:1863–1871. ( IF= 3.554,期刊排名:2 / 165, Veterinary, 1區.第6作者)

  35、Chengmin Wang, Lyu N, Deng L, Wang J, Gu W, Ding H, Wu Y, Luo J, Wang L,Lyv X, Liu X, Tao Y and He H. Evolutionary Pattern and Large-Scale Architecture of Mutation Networks of 2009 A (H1N1) Influenza A Virus. Front. Genet. 2018, 9:204. (IF=4.151,期刊排名:31/176, Genetics & Heredity,1區,第1作者)

  36、Chengmin Wang, pengpeng liu, Jing Luo, Hua Ding, yan gao, Lei Sun, fubing luo, xiaodong liu and Hongxuan He. Geldanamycin reduces acute respiratory distress syndrome and promotes the survival for of mice infected with the highly virulent H5N1 influenza virus. Front. Cell. Infect. Microbiol.2017, 7:267.IF=5.218,期刊排名:25/124, Microbiology,1區,第1作者

  37、Chengmin Wang , Huimin Liu, Jing Luo, Lin Chen, Meng Li, Wen Su, Na Zhao , Shelan Liu , Li Xie , Yaxiong Jia , Hua Ding , Xiufeng Wan , Hongxuan He. HA Triggers the Switch from MEK1 SUMOylation to Phosphorylation of the ERK Pathway in Influenza A Virus-Infected Cells and Facilitates Its Infection. Front. Cell. Infect. Microbiol. 2017,7:27. (IF=5.218,期刊排名:25/124, Microbiology,1區,第1作者)

  38、Chengmin Wang, Yanyu Zhang, Jing Luo, Hua Ding, Shelan Liu, Said Amer, Li Xie,Wenting Lyv, Wen Su, Meng Li, Qinmiao Sun, Jiayin Dai & Hongxuan He.Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection. Scientific reports.2016 ,6:24854. (IF=5.228,期刊排名:7/62, Multidisciplinary Sciences.1區.第1作者)

  39、Chengmin Wang, Jing Luo, Haijing Wang, Said Amer, Hua DING, Ying Dong, and Hongxuan He. Isolation and characterization of a Neisseria.sp from the captive wild goose (Anser anser).Integr Zool. 2016,11(2):128-33.(IF=1.722,期刊排名:38/161, Zoology,1區,第1作者)

  40、Chengmin Wang, Jing Wang, Wen Su, Shanshan Gao, Jing Luo, Min Zhang, Li Xie, Shelan Liu, Xiaodong Liu, Yu Chen, Yaxiong Jia, Hong Zhang, Hua Ding, Hongxuan He. Relationship between domestic and wild birds in live poultry market and a novel human H7N9 virus in China. J Infect Dis. 2014,209(1):34-7. (IF=5.778,期刊排名:5/72,Infectious Diseases,1區,第1作者)

  41、Chengmin Wang, Yanyu Zhang, Bin Wu, Shelan Liu, Ping Xu, Yanmin Lu, Jing Luo, Dale Louis Nolte, Thomas Jude Deliberto, Mingxing Duan, Hong Zhang, Hongxuan He.Evolutionary Characterization of the Pandemic H1N1/2009 Influenza Virus in Humans Based on Non-Structural Genes. PLoS ONE. 2013;8(2):e56201.(IF=3.73,期刊排名:7/56,Multidisciplinary Sciences,1區,第1作者)

  42、Chengmin Wang, Jing Luo, Said Amer, Yunhai Guo, Yi Hu, Yanmin Lu, Haijing Wang, Mingxing Duan, Hongxuan He.Multivalent DNA vaccine induces protective immune responses and enhanced resistance against Cryptosporidium parvum infection. Vaccine. 2011,29, 323–328. (IF=3.572,期刊排名:25/106, Medicine, Research & Experimental,1區,第1作者)

  43、Chengmin Wang, Yanyun Wu, Jianhua Qin, Haoxue Sun, Hongxuan He. Induced Susceptibility of Host Is Associated with an Impaired Antioxidant System Following Infection with Cryptosporidium parvum in Se-Deficient Mice. PLoS ONE. 2009,4(2): e4628.(.IF=4.351,期刊排名:10/76, Biology,1區,第1作者)

  44、Lin Chen, Chengmin Wang, Jing Luo, Wen Su, Meng Li, Na Zhao, Wenting Lyu , Attaran H, Yapeng He, Hua Ding and Hongxuan He. Histone Deacetylase 1 Plays an Acetylation- Independent Role in Influenza A Virus Replication.Front. Immunol.2017, 8:1757 (IF=6.429,期刊排名:21/151,Immunology,1區,第1作者(共同))

  45、Shelan Liu, Chengliang Chai, Chengmin Wang, Said Amer,Huakun Lv, Hongxuan He, Jimin Sun and Junfen Lin.Systematic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics. Reviews in Medical Virology. 2014,24: 90–102 (IF=5.759,期刊排名:5/33,Virology,1區,第1作者(共同))

  46、Bin Wu, Chengmin Wang, Guoying Dong, Yunhai Guo, Dale Louis Nolte, Thomas Jude Deliberto, Jianguo Xu,Mingxing Duan, Hongxuan He.New Evidence Suggests Southern China as a Common Source of Multiple Clusters of Highly Pathogenic H5N1 Avian Influenza Virus. Journal of Infectious diseases. 2010,202:452–458(IF=6.228,期刊排名:5/58,Infectious Diseases,1區,第1作者(共同))

  47、Chengmin Wang, Jing Luo,Jing Wang,Wen Su, Shanshan Gao, Min Zhang, Li Xie,Hua Ding,Shelan Liu,Xiaodong Liu,Yu Chen,Yaxiong Jia,Hongxuan He. Novel human H7N9 influenza virus in China. Integrative Zoology.2014,9: 372–375 (IF=1.419,期刊排名:47/153, Zoology,2區,第1作者)

  48、Chengmin Wang,Hongxuan He Leptospira spp. In Commensal Rodents, Beijing, China. J Wildl Dis. 2013,49(2):461-3. (IF=1.271,期刊排名:48/143, Veterinary Sciences,2區,第1作者)

  授權發明專利:

  1.陳金平,李林妙,覃茂林,劉燈紅. 國家發明專利:一種施氏鱘雌魚和匙吻鱘雄魚雜交育苗方法. 專利號:ZL201710698134.9;授權公告日:2020.1.7.

  2.張秀娟、陳金平、吳文化、周佳濱、李林妙. 國家發明專利:江海英鑒定鱘魚性別的microRNA血清標志物、引物組、試劑盒及其應用. 專利號:ZL202010314533.2;授權公告日:2020.7.24.

  3.張秀娟、陳金平、白銀山、張守全、王承民. 國家發明專利:一種利用FACT Ⅲ微載體體外擴增精原干細胞的三維動態培養方法. 專利號:ZL202010314524.3;授權公告日:2020.7.31.

  4.原麗紅,李林妙.日本專利:一條D螺旋區突變的瘦素活性肽及其編碼基因和應用.專利號:特許第6486482號;授權公告日:2019.3.1.

  5.原麗紅,李林妙.日本專利:一條D螺旋區突變的瘦素活性肽及其編碼基因和應用.專利號:ZL201510228121.6;授權公告日:2017.11.28.

  6.原麗紅,陳金平. 國家發明專利:一條 CD 環和 E 螺旋區突變的瘦素活性肽及其編碼基因和應用.專利號:ZL201510228093.8;授權公告日:2017.11.06.

  7.原麗紅,張樹義,陳金平,林本夫,左學國,何靈江. 國家發明專利:棕果蝠瘦素蛋白及其cDNA序列. 專利號:ZL200910039440.7; 授權公告日:2011.08.24.

  8.原麗紅,張樹義,林本夫,何靈江,左學國,陳金平. 國家發明專利:馬鐵菊頭蝠瘦素蛋白及其cDNA序列. 專利號:ZL200910039438.X, 授權公告日:2011.09.28.

  9. 原麗紅,張樹義,林本夫,左學國,何靈江,陳金平. 國家發明專利:長翼蝠瘦素蛋白及其cDNA序列, 專利號:ZL200910039439.4, 授權公告日:2011.08.24.

  10. 吳文化,孫大江,張穎,宋聃,陳金平,王念民. 國家發明專利:一種達氏鰉苗種的低溫馴化培育方法, 專利號:ZL201310533824.0, 授權公告日:2016.03.23.

  11. 原麗紅,陳金平,一條CD環和E螺旋區突變的瘦素活性肽及其編碼基因和應用,PCT專利(PCT/CN2015/088554),優先權日2015.5.7,已申請進入日本,日本申請號:2017-540624。

 

  

    

  

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